I'm not real active on that site---mostly because it's been my experience that the people who tweet the most frequently, generally, have the least interesting things to say---but I do post there from time to time, I've had some pleasant exchanges with some people, and I've developed some fairly simple rules for keeping your sanity there:
1. Only follow people whose work you admire.
2. Only engage people when you have a question that they might know the answer to, or to correct them if you think they may be in error.
3. Engage respectfully (see Rule #1). Life is too short for flame wars and trolling, and you'll see enough hateful bilge being retweeted by others in your your timeline.
4. Be generous in your endorsements. The people you call out for praise will appreciate it, even when it comes from a minor-leaguer like me.
That's about it. I know this will strike most of you as plain-old common sense, but it's amazing how little there often is of it at Twitter. It reminds me in many ways of high school inasmuch as people tend to form these tribe-like "cliques" that all claim to be the most righteous and perceptive on the Interwebs. I prefer, by contrast, to remain a lone wolf.
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Baron V